Cγ-Aminopropylene peptide nucleic acid (amp-PNA): chiral cationic PNAs with superior PNA:DNA/RNA duplex stability and cellular uptake

JAIN, DEEPAK R.; KUMAR, PRAMOD

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dc.contributor.author	KUMAR, PRAMOD	en_US
dc.contributor.author	JAIN, DEEPAK R.	en_US
dc.date.accessioned	2020-10-26T06:38:21Z
dc.date.available	2020-10-26T06:38:21Z
dc.date.issued	2015-05	en_US
dc.identifier.citation	Tetrahedron, 71(21), 3378-3384.	en_US
dc.identifier.issn	0040-4020	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5281
dc.identifier.uri	https://doi.org/10.1016/j.tet.2015.03.093	en_US
dc.description.abstract	Inherently cationic and chiral Cγ-aminopropylene peptide nucleic acid (amp-PNA) have been synthesized with three carbon spacer chain from the backbone. The modified amp-PNAs have shown to stabilize (ΔTm) the PNA:DNA duplexes better than that of corresponding PNA:RNA duplexes. However, the PNA:RNA duplexes have higher thermal stability (Tm) compared to PNA:DNA duplexes for both modified and unmodified PNAs. The live cell imaging of amp-PNAs demonstrated their effective penetration inside the MCF-7 cells and found to be accumulated in the vicinity of the nuclear membrane in the cytoplasm.	en_US
dc.language.iso	en	en_US
dc.publisher	Elsevier B.V.	en_US
dc.subject	Cationic PNA	en_US
dc.subject	Spacer chain	en_US
dc.subject	DNA/RNA hybridization	en_US
dc.subject	Cell penetration	en_US
dc.subject	2015	en_US
dc.title	Cγ-Aminopropylene peptide nucleic acid (amp-PNA): chiral cationic PNAs with superior PNA:DNA/RNA duplex stability and cellular uptake	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Biology	en_US
dc.identifier.sourcetitle	Tetrahedron	en_US
dc.publication.originofpublisher	Foreign	en_US