Gliolectin positively regulates Notch signalling during wing-vein specification in Drosophila

PRASAD, NAVEEN; SHASHIDHARA, L.S.

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dc.contributor.author	PRASAD, NAVEEN	en_US
dc.contributor.author	SHASHIDHARA, L.S.	en_US
dc.date.accessioned	2020-10-26T06:38:37Z
dc.date.available	2020-10-26T06:38:37Z
dc.date.issued	2015	en_US
dc.identifier.citation	International Journal of Developmental Biology, 59(4-6), 187-194.	en_US
dc.identifier.issn	0214-6282	en_US
dc.identifier.issn	1696-3547	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5304
dc.identifier.uri	https://doi.org/10.1387/ijdb.140190LS	en_US
dc.description.abstract	Notch signalling is essential for animal development. It integrates multiple pathways controlling cell fate and specification. Here we report the genetic characterization of Gliolectin, presumably a lectin, a cytoplasmic protein, significantly enriched in Golgi bodies. Its expression overlaps with regions where Notch is activated. Loss of gliolectin function results in ectopic veins, while gain of its function causes loss of wing veins. It positively regulates Enhancer of split m beta, a target of Notch signalling. These observations suggest that it is a positive regulator of Notch signalling during wing development in Drosophila.	en_US
dc.language.iso	en	en_US
dc.publisher	University of the Basque Country UPV/EHU Press	en_US
dc.subject	Glec	en_US
dc.subject	Notch	en_US
dc.subject	Wing vein development	en_US
dc.subject	D/V boundary	en_US
dc.subject	2015	en_US
dc.title	Gliolectin positively regulates Notch signalling during wing-vein specification in Drosophila	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Biology	en_US
dc.identifier.sourcetitle	International Journal of Developmental Biology	en_US
dc.publication.originofpublisher	Foreign	en_US