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Prebiological Membranes and Their Role in the Emergence of Early Cellular Life

Show simple item record SARKAR, SUSOVAN en_US DAS, SOURADEEP en_US DAGAR, SHIKHA en_US JOSHI, MANESH PRAKASH en_US MUNGI, CHAITANYA V. en_US SAWANT, ANUPAM A. en_US PATKI, GAURI M. en_US RAJAMANI, SUDHA en_US 2020-12-04T11:39:56Z 2020-12-04T11:39:56Z 2020-11 en_US
dc.identifier.citation Journal of Membrane Biology, 253, 589–608. en_US
dc.identifier.issn 0022-2631 en_US
dc.identifier.issn 1432-1424 en_US
dc.identifier.uri en_US
dc.description.abstract Membrane compartmentalization is a fundamental feature of contemporary cellular life. Given this, it is rational to assume that at some stage in the early origins of life, membrane compartments would have potentially emerged to form a dynamic semipermeable barrier in primitive cells (protocells), protecting them from their surrounding environment. It is thought that such prebiological membranes would likely have played a crucial role in the emergence and evolution of life on the early Earth. Extant biological membranes are highly organized and complex, which is a consequence of a protracted evolutionary history. On the other hand, prebiotic membrane assemblies, which are thought to have preceded sophisticated contemporary membranes, are hypothesized to have been relatively simple and composed of single chain amphiphiles. Recent studies indicate that the evolution of prebiotic membranes potentially resulted from interactions between the membrane and its physicochemical environment. These studies have also speculated on the origin, composition, function and influence of environmental conditions on protocellular membranes as the niche parameters would have directly influenced their composition and biophysical properties. Nonetheless, the evolutionary pathways involved in the transition from prebiological membranes to contemporary membranes are largely unknown. This review critically evaluates existing research on prebiotic membranes in terms of their probable origin, composition, energetics, function and evolution. Notably, we outline new approaches that can further our understanding about how prebiotic membranes might have evolved in response to relevant physicochemical parameters that would have acted as pertinent selection pressures on the early Earth. en_US
dc.language.iso en en_US
dc.publisher Springer Nature en_US
dc.subject Prebiotic membranes en_US
dc.subject Molecular evolution en_US
dc.subject Early cellular life en_US
dc.subject 2020 en_US
dc.subject 2020-DEC-WEEK1 en_US
dc.subject TOC-DEC-2020 en_US
dc.title Prebiological Membranes and Their Role in the Emergence of Early Cellular Life en_US
dc.type Article en_US
dc.contributor.department Dept. of Biology en_US
dc.identifier.sourcetitle Journal of Membrane Biology en_US
dc.publication.originofpublisher Foreign en_US

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