dc.contributor.author |
JAIN, PRASHANT |
en_US |
dc.contributor.author |
SHANTHAMURTHY, CHETHAN D. |
en_US |
dc.contributor.author |
CHAUDHARY, PREETI MADHUKAR |
en_US |
dc.contributor.author |
KIKKERI, RAGHAVENDRA |
en_US |
dc.date.accessioned |
2021-03-04T11:47:01Z |
|
dc.date.available |
2021-03-04T11:47:01Z |
|
dc.date.issued |
2021-03 |
en_US |
dc.identifier.citation |
Chemical Science, 12(11), 4021-4027. |
en_US |
dc.identifier.issn |
2041-6539 |
en_US |
dc.identifier.uri |
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5695 |
|
dc.identifier.uri |
https://doi.org/10.1039/D1SC00140J |
en_US |
dc.description.abstract |
The aberrant expression of endocytic epidermal growth factor receptors (EGFRs) in cancer cells has emerged as a key target for therapeutic intervention. Here, we describe for the first time a state-of-the-art design for a heparan sulfate (HS) oligosaccharide-based nanovehicle to target EGFR-overexpressed cancer cells in cellular heterogeneity. An ELISA plate IC50 inhibition assay and surface plasma resonance (SPR) binding assay of structurally well-defined HS oligosaccharides showed that 6-O-sulfation (6-O-S) and 6-O-phosphorylation (6-O-P) of HS tetrasaccharides significantly enhanced EGFR cognate growth factor binding. The conjugation of these HS ligands to multivalent fluorescent gold nanoparticles (AuNPs) enabled the specific and efficient targeting of EGFR-overexpressed cancer cells. In addition, this heparinoid-nanovehicle exhibited selective homing to NPs in cancer cells in three-dimensional (3D) coculture spheroids, thus providing a novel target for cancer therapy and diagnostics in the tumor microenvironment (TME). |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Royal Society of Chemistry |
en_US |
dc.subject |
Chemistry |
en_US |
dc.subject |
2021-MAR-WEEK1 |
en_US |
dc.subject |
TOC-MAR-2021 |
en_US |
dc.subject |
2021 |
en_US |
dc.title |
Rational designing of glyco-nanovehicles to target cellular heterogeneity |
en_US |
dc.type |
Article |
en_US |
dc.contributor.department |
Dept. of Chemistry |
en_US |
dc.identifier.sourcetitle |
Chemical Science |
en_US |
dc.publication.originofpublisher |
Foreign |
en_US |