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An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India

Show simple item record Yadav, Pragya D. en_US GOPAL, ANJANI et al. en_US 2021-06-11T04:37:27Z 2021-06-11T04:37:27Z 2021-05 en_US
dc.identifier.citation Viruses, 13(5), 925. en_US
dc.identifier.issn 1999-4915 en_US
dc.identifier.uri en_US
dc.description.abstract The number of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) cases is increasing in India. This study looks upon the geographic distribution of the virus clades and variants circulating in different parts of India between January and August 2020. The NPS/OPS from representative positive cases from different states and union territories in India were collected every month through the VRDLs in the country and analyzed using next-generation sequencing. Epidemiological analysis of the 689 SARS-CoV-2 clinical samples revealed GH and GR to be the predominant clades circulating in different states in India. The northern part of India largely reported the ‘GH’ clade, whereas the southern part reported the ‘GR’, with a few exceptions. These sequences also revealed the presence of single independent mutations—E484Q and N440K—from Maharashtra (first observed in March 2020) and Southern Indian States (first observed in May 2020), respectively. Furthermore, this study indicates that the SARS-CoV-2 variant (VOC, VUI, variant of high consequence and double mutant) was not observed during the early phase of virus transmission (January–August). This increased number of variations observed within a short timeframe across the globe suggests virus evolution, which can be a step towards enhanced host adaptation. en_US
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.subject SARS-CoV-2 en_US
dc.subject Epidemiology en_US
dc.subject NGS en_US
dc.subject Clades en_US
dc.subject India en_US
dc.subject 2021-JUN-WEEK2 en_US
dc.subject TOC-JUN-2021 en_US
dc.subject 2021 en_US
dc.title An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India en_US
dc.type Article en_US
dc.contributor.department Dept. of Biology en_US
dc.identifier.sourcetitle Viruses en_US
dc.publication.originofpublisher Foreign en_US

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