Digital Repository

Deciphering the role of oxidative stress response in bactericidal antibiotic resistance

Show simple item record

dc.contributor.advisor RADHAKRISHNAN, SUNISH KUMAR en_US
dc.contributor.author VADAPALLI, SIRISHA en_US
dc.date.accessioned 2021-07-08T11:17:39Z
dc.date.available 2021-07-08T11:17:39Z
dc.date.issued 2021-05
dc.identifier.citation 34 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/6048
dc.description.abstract In addition to acting on the primary targets, recent evidence indicates that bactericidal antibiotics such as kanamycin, norfloxacin, ampicillin have the ability to induce oxidative stress in bacterial cells, which in turn may increase the killing efficacy of the antibiotics. However, it remains to be understood if the oxidative stress response mechanisms in bacteria play any role in enhancing the resistance of bacterial cells towards the antibiotic. The oxidative stress response regulator, OxyR, plays a major role in overcoming the oxidative stress response in bacteria. Using a gain-of-function mutant of OxyR from Caulobacter crescentus, this work attempts to dissect the mechanism and role of OxyR during antibiotic-induced oxidative stress. en_US
dc.language.iso en_US en_US
dc.subject Antibiotic resistance en_US
dc.subject Oxidative stress en_US
dc.subject OxyR en_US
dc.title Deciphering the role of oxidative stress response in bactericidal antibiotic resistance en_US
dc.type Thesis en_US
dc.type.degree BS-MS en_US
dc.contributor.department Dept. of Biology en_US
dc.contributor.registration 20151030 en_US


Files in this item

This item appears in the following Collection(s)

  • MS THESES [1705]
    Thesis submitted to IISER Pune in partial fulfilment of the requirements for the BS-MS Dual Degree Programme/MSc. Programme/MS-Exit Programme

Show simple item record

Search Repository


Advanced Search

Browse

My Account