Abstract:
Aromatic heterocyclic rings are the backbone of various natural products and biologically active compounds. And, these compounds are made up of carbon-carbon or carbon-heteroatom bonds. Transition metal catalysed reactions are one of the efficient ways to construct these bonds. Annulation via chelation-assisted C-H bond activation is a most effective pathway in the synthesis of heterocyclic compounds since the synthesis of tri-heterocyclic rings is still limited in the literature. Here we reported the formation of a tri-heterocyclic ring, dibenzothiazines through the cyclisation of phenyl sulfoximine into benzyne ring in the presence of Palladium acetate, potassium persulfate and Pivalic acid at 110-degree celius.
