Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive and fatal disease, caused by the degeneration of upper and lower motor neurons within the brain and spinal cord in the ageing human. The dying neurons contain ...
Proper formation and specification of Primordial Germ Cells (PGCs) is of special significance as they gradually transform into Germline Stem Cells (GSCs) that are ultimately responsible for generating the gametes. Intriguingly, ...
Dopaminergic (DAergic) neurodegeneration in the substantia nigra pars compacta of the human brain is the pathological feature associated with Parkinson’s disease (PD). Drosophila also exhibits mobility defects and diminished ...
PURI, SARITA; Gadda, Angela et al.(Elsevier B.V., 2025-03)
Light chain (AL) amyloidosis is the most common systemic amyloid disease characterized by abnormal accumulation of amyloid fibrils derived from immunoglobulin light chains (LCs). Both full-length (FL) LCs and their isolated ...
A search for Higgs boson pair (HH) production in association with a vector boson V (W or Z boson) is presented. The search is based on proton-proton collision data at a enter-of-mass energy of 13 TeV, collected with the ...
Paissoni, Cristina; SARITA PURI et al.(eLife Sciences Publications Ltd., 2025-03)
Both immunoglobulin light-chain (LC) amyloidosis (AL) and multiple myeloma (MM) share the overproduction of a clonal LC. However, while LCs in MM remain soluble in circulation, AL LCs misfold into toxic-soluble species and ...
PURI, SARITA; Hsu, Shang-Te Danny(Frontiers Media S.A., 2024-11)
Ubiquitin C-terminal hydrolases (UCHs) are crucial enzymes within the ubiquitin-proteasome system, characterized by a characteristic Gordian knotted topology. Another important structural feature of the UCH family is a ...
Koner, Kalipada; SURY, ADHRA; PILLAI, PRAMOD P. et al.(American Chemical Society, 2025-03)
Two-dimensional organic materials are mainly constructed by using orthogonal anisotropic connectivity of covalent bonding and π–π stacking. The noncovalent connectivity between building blocks is presumed to be too delicate ...
Halide perovskites have recently evolved as attractive materials with enormous technological significance due to synthetic control over the structure–property relationship. Halide perovskites are often realized to be either ...
SHUKLA, ASHUTOSH; CHAND, RAHUL; BOBY, SNEHA; KUMAR, G. V. PAVAN(American Chemical Society, 2025-03)
Optical tweezers have revolutionized particle manipulation at the micro- and nanoscale, playing a critical role in fields such as plasmonics, biophysics, and nanotechnology. While traditional optical trapping methods ...
Precise measurements of ocean surface flow velocities are essential for refining forecasts in a coupled ocean–atmosphere system. While oceanic data are generally sparse, surface drifters present an opportunity by providing ...
The recovery of radioactive iodine from nuclear waste and contaminated water sources is a critical environmental concern, which poses significant technical challenges. Herein, the study has demonstrated that tuning the ...
CMS Collaboration; Hayrapetyan, A.; ACHARYA, S.; ALPANA, A.; DUBE, SOURABH; GOMBER, B; HAZARIKA, P.; KANSAL, B.; LAHA, A.; SAHU, B.; SHARMA, SEEMA; VAISH, K. Y. et al.(American Physical Society, 2024-12)
Measurements of the polarization and spin correlation in top quark pairs (𝑡¯𝑡) are presented using events with a single electron or muon and jets in the final state. The measurements are based on proton-proton collision ...
RAZA, AKRAM; CHATTOPADHAYAY, SANDIP; MONDAL, DEBASHIS; TALUKDAR, PINAKI(Royal Society of Chemistry, 2025-03)
Herein, we introduced a series of carbonohydrazonoyl dicyanide-linked indole carboxamide 1a–1c transporters. Detailed mechanistic insight into the transport manifested that superior transporter 1a facilitates the movement ...
Fall, Birane; PRAKASH, PRABHAT; VENKATNATHAN, ARUN et al.(American Chemical Society, 2025-02)
The solid lithium-ion electrolytes (Adpn)2LiXF6 (Adpn = adiponitrile, X = P, As, Sb) are isomorphic salt-solvate cocrystals with slight differences in lattice spacing (<0.15 Å). The Li+ cations are coordinated by Adpn ...
SAMANTA, RANITA; PANDAY, RISHUKUMAR; BOOMISHANKAR, RAMAMOORTHY et al.(Wiley, 2025-03)
Molecular ferroelectrics are of enormous interest due to their ease of synthesis and simplicity in device fabrication. Here, the non-volatile memory effect in a polycrystalline thin film of the single-component ferroelectric ...
McFadden, David; PODDER, SANTOSH et al.(Protocols.io, 2025-01)
The protocols in this collection describe how to measure and analyze the photon conversation factor (PCF photo-electrons/count), readnoise, and dynamic range of a light microscopy detection system; which can either be a ...
We construct maximal supergravity in five-dimensions by ‘oxidizing’ the four-dimensional = 8 theory. The relevant symmetries, the unitary symplectic group USp(8) and the exceptional group E6, are both presented in light-cone ...
Hydrogen evolution reaction (HER) is a key reaction in electrochemical water splitting for hydrogen production leading to the development of potentially sustainable energy technology. Importantly, the catalysts required ...
A search for electroweak production of a single vectorlike 𝑇 quark in association with a bottom (𝑏) quark in the all-hadronic decay channel is presented. This search uses proton-proton collision data at √𝑠 =13 TeV ...