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Now showing items 1-9 of 9

Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism

Kory, Nora; KAMAT, SIDDHESH S. et al. (American Society for Biochemistry and Molecular Biology, 2017-01)

Variations in the gene LDAH (C2ORF43), which encodes lipid droplet-associated hydrolase (LDAH), are among few loci associated with human prostate cancer. Homologs of LDAH have been identified as proteins of lipid droplets ...
Introducing "Future of Biochemistry 2020: The Asia-Pacific Issue"

Schepartz, Alanna; KAMAT, SIDDHESH S. et al. (American Chemical Society, 2020-01)

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Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition

Kinatukara, Priyadarshan; SINGH, SHUBHAM; MHETRE, AMOL; KAMAT, SIDDHESH S. et al. (Springer Nature, 2020-11)

Disco-interacting protein 2 is a highly conserved three-domain protein with two tandem Adenylate-forming domains. It is proposed to influence the processes involved in neuronal development by influencing lipid metabolism ...
Mycobacterium tuberculosis Transcription Factor EmbR Regulates the Expression of Key Virulence Factors That Aid in Ex Vivo and In Vivo Survival

Kumar, Suresh; KHANDELWAL, NEHA; KAMAT, SIDDHESH S. et al. (American Society for Microbiology, 2022-04)

Mycobacterium tuberculosis encodes ~200 transcription factors that modulate gene expression under different microenvironments in the host. Even though high-throughput chromatin immunoprecipitation sequencing and transcriptome ...
DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes

Mondal, Sudipta; SINGH, SHUBHAM; KAMAT, SIDDHESH S. et al. (eLife Sciences Publications Ltd., 2022-06)

Chain-length specific subsets of diacylglycerol (DAG) lipids are proposed to regulate differential physiological responses ranging from signal transduction to modulation of the membrane properties. However, the mechanism ...
Metabolic regulation of CTCF expression and chromatin association dictates starvation response in mice and flies

Sen, Devashish; CHAKRABORTY, ARNAB; MEHENDALE, NEELAY; KAMAT, SIDDHESH S. et al. (Elsevier B.V., 2023-06)

Coordinated temporal control of gene expression is essential for physiological homeostasis, especially during metabolic transitions. However, the interplay between chromatin architectural proteins and metabolism in regulating ...
ACSL4-mediated H3K9 and H3K27 hyperacetylation upregulates SNAIL to drive TNBC metastasis

Sinha, Abhipsa; CHANDRAMOULI, AAKASH; KAMAT, SIDDHESH S. et al. (National Academy of Sciences, 2024-12)

Triple-negative breast cancer (TNBC) has profound unmet medical need globally for its devastating clinical outcome associated with rapid metastasis and lack of targeted therapies. Recently, lipid metabolic reprogramming ...
Thoughts for the future

Alkhalaf, Lona M.; KAMAT, SIDDHESH S. et al. (Springer Nature, 2025-01)

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Inhibiting de novo lipogenesis identifies a therapeutic vulnerability in therapy-resistant colorectal cancer

Jog, Eeshrita; CHAKRABORTY, ARNAB; KAMAT, SIDDHESH S. et al. (Elsevier B.V., 2025-02)

A significant clinical challenge in patients with colorectal cancer (CRC), which adversely impacts patient survival, is the development of therapy resistance leading to a relapse. Therapy resistance and relapse in CRC is ...

Now showing items 1-9 of 9

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