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  • Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones 
    KHODADE, VINAYAK S.; DHARMARAJA, ALLIMUTHU T.; CHAKRAPANI, HARINATH (Elsevier B.V., 2012-06)
    Here we report a series of 2-aryl-3-amino-1,4-naphthoquinones that generated reactive oxygen species (ROS) such as superoxide and hydrogen peroxide upon incubation in pH 7.4 under ambient aerobic conditions. ROS generation ...
  • Bioreductively Activated Reactive Oxygen Species (ROS) Generators as MRSA Inhibitors 
    KHODADE, VINAYAK S.; Chandra, Mallojjala Sharath; Banerjee, Ankita; Lahiri, Surobhi; Pulipeta, Mallikarjuna; CHAKRAPANI, HARINATH; Rangarajan, Radha (American Chemical Society, 2014-07)
    The number of cases of drug resistant Staphylococcus aureus infections is on the rise globally and new strategies to identify drug candidates with novel mechanisms of action are in urgent need. Here, we report the synthesis ...
  • A Small Molecule for Controlled Generation of Peroxynitrite 
    KHODADE, VINAYAK S.; Kulkarni, Apoorva; Sen Gupta, Ayantika; SENGUPTA, KUNDAN; CHAKRAPANI, HARINATH (American Chemical Society, 2016-03)
    2-Methyl-3-[1-(N,N-dimethylamino)diazen-1-ium-1,2-diol-2-ato-methyl]-naphthalene-1,4-dione 1 (HyPR-1), a small molecule containing a superoxide generator strategically linked to a diazeniumdiolate-based nitric oxide donor, ...
  • “On demand” redox buffering by H2S contributes to antibiotic resistance revealed by a bacteria-specific H2S donor 
    Shukla, Prashant; KHODADE, VINAYAK S.; Chandra, Mallojjala Sharath; Chauhan, Preeti; Mishra, Saurabh; Siddaramappa, Shivakumara; Pradeep, Bulagonda Eswarappa; Singh, Amit; CHAKRAPANI, HARINATH (Royal Society of Chemistry, 2017-04)
    Understanding the mechanisms of antimicrobial resistance (AMR) will help launch a counter-offensive against human pathogens that threaten our ability to effectively treat common infections. Herein, we report bis(4-nitrob ...

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