Hi-C is a widely used technique for mapping chromosomal interactions within a 3D genomic framework, however, its resolution is often constrained by sequencing depth, making it challenging to detect fine-scale interactions. ...

Polyzwitterions (PZs)─polymers bearing both positive and negative charges within each repeating unit─exhibit an unusual antipolyelectrolyte effect where their solubility and viscosity increase upon the addition of salt, ...

We present a theoretical study of the collective excitations of the supersolid annular stripe phase of a spin-orbital-angular-momentum-coupled (SOAM-coupled) spin-1 Bose-Einstein condensate. The annular stripe phase ...

Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive and fatal disease, caused by the degeneration of upper and lower motor neurons within the brain and spinal cord in the ageing human. The dying neurons contain ...

Proper formation and specification of Primordial Germ Cells (PGCs) is of special significance as they gradually transform into Germline Stem Cells (GSCs) that are ultimately responsible for generating the gametes. Intriguingly, ...

Ubiquitin C-terminal hydrolases (UCHs) are crucial enzymes within the ubiquitin-proteasome system, characterized by a characteristic Gordian knotted topology. Another important structural feature of the UCH family is a ...

Both immunoglobulin light-chain (LC) amyloidosis (AL) and multiple myeloma (MM) share the overproduction of a clonal LC. However, while LCs in MM remain soluble in circulation, AL LCs misfold into toxic-soluble species and ...

Two-dimensional organic materials are mainly constructed by using orthogonal anisotropic connectivity of covalent bonding and π–π stacking. The noncovalent connectivity between building blocks is presumed to be too delicate ...

Precise measurements of ocean surface flow velocities are essential for refining forecasts in a coupled ocean–atmosphere system. While oceanic data are generally sparse, surface drifters present an opportunity by providing ...

Herein, we introduced a series of carbonohydrazonoyl dicyanide-linked indole carboxamide 1a–1c transporters. Detailed mechanistic insight into the transport manifested that superior transporter 1a facilitates the movement ...