SINGH, YASHASWI; SARKAR, DEBAYAN; Duari, Subhadeep; G. Shashaank; Guru, Pawas Kumar Indra; M V, Hrishikesh; Singh, Dheerendra; Bhardwaj, Sahil; KALIA, JEET
(Journal of Biological Chemistry, 2023-07)
The spider venom protein, double-knot toxin (DkTx), partitions into the cellular membrane and binds bivalently to the pain-sensing ion channel, TRPV1, triggering long-lasting channel activation. In contrast, its monovalent ...