Ghosh, Arijit; Bhattacharjee, Sangheeta; Chowdhuri, Srijita Paul; MALLICK, ABHIK; Rehman, Ishita; Basu, Sudipta; Das, Benu Brata
(American Association for the Advancement of Science, 2019-11)
A homozygous mutation of human tyrosyl-DNA phosphodiesterase 1 (TDP1) causes the neurodegenerative syndrome, spinocerebellar ataxia with axonal neuropathy (SCAN1). TDP1 hydrolyzes the phosphodiester bond between DNA 3′-end ...