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  • SUMO-Enriched Proteome for Drosophila Innate Immune Response 
    Handu, Mithila; KADUSKAR, BHAGYASHREE; Ravindranathan, Ramya; Soory, Amarendranath; Giri, Ritika; Elango, Vijay Barathi; Gowda, Harsha; RATNAPARKHI, GIRISH S. (The Genetics Society of America, 2015-10)
    Small ubiquitin-like modifier (SUMO) modification modulates the expression of defense genes in Drosophila, activated by the Toll/nuclear factor-κB and immune-deficient/nuclear factor-κB signaling networks. We have, however, ...
  • Drosophila DNA/RNA methyltransferase contributes to robust host defense in ageing animals by regulating sphingolipid metabolism 
    Varada, Abhyankar; KADUSKAR, BHAGYASHREE; KAMAT, SIDDHESH S.; Deobagkar, Deepti; RATNAPARKHI, GIRISH S. (The Company of Biologists Ltd, 2018-09)
    Drosophila methyltransferase (Mt2) has been implicated in methylation of both DNA and tRNA. In this study, we demonstrate that loss of Mt2 activity leads to an age dependent decline of immune function in the adult fly. A ...
  • SUMO conjugation regulates immune signalling 
    HEGDE, SUSHMITHA; SOORY, AMARENDRANATH; KADUSKAR, BHAGYASHREE; RATNAPARKHI, GIRISH S. (Taylor & Francis, 2020-08)
    Post-translational modifications (PTMs) are critical drivers and attenuators for proteins that regulate immune signalling cascades in host defence. In this review, we explore functional roles for one such PTM, the small ...
  • Caspar SUMOylation regulates Drosophila lifespan 
    KADUSKAR, BHAGYASHREE; Trivedi, Deepti; RATNAPARKHI, GIRISH S. (Caltech Library, 2020-08)
    Casp is a negative regulator of IMD/NFkB signaling. Casp negatively regulates DREDD activity. DREDD is the protease responsible for cleavage/maturation of Relish (Rel), in response to IMD signaling and leads to the subsequent ...
  • Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NFκB-mediated glial inflammation in a Drosophila model of human disease 
    TENDULKAR, SHWETA; HEGDE, SUSHMITHA; GARG, LOVLEEN; THULASIDHARAN, APARNA; KADUSKAR, BHAGYASHREE; Ratnaparkhi, Anuradha; RATNAPARKHI, GIRISH S. (Oxford University Press, 2022-09)
    Amyotrophic lateral sclerosis (ALS) is a fatal, late-onset, progressive motor neurodegenerative disorder. A key pathological feature of the disease is the presence of heavily ubiquitinated protein inclusions. Both the ...

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