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  • Continuous-Flow Accelerated Sulfation of Heparan Sulfate Intermediates 
    ANAND, SAURABH; MARDHEKAR, SANDHYA; RAIGAWALI, RAKESH; MOHANTA, NIRMALA; JAIN, PRASHANT; SHANTHAMURTHY, CHETHAN D.; GNANAPRAKASAM, BOOPATHY; KIKKERI, RAGHAVENDRA (American Chemical Society, 2020-04)
    We report for the first time a continuous-flow strategy to execute O-sulfation modification of heparan sulfate (HS) oligosaccharides. A systematic investigation of the influence of the flow parameters on the installation ...
  • Profiling Heparan Sulfate-Heavy Metal Ions Interaction Using Electrochemical Techniques 
    Shitrit, Ariel; MARDHEKAR, SANDHYA; Alshanski, Israel; JAIN, PRASHANT; RAIGAWALI, RAKESH; SHANTHAMURTHY, CHETHAN D.; KIKKERI, RAGHAVENDRA; Yitzchaik, Shlomo; Hurevich, Mattan (Wiley, 2022-10)
    Heparan sulfate glycosaminoglycans provides extracellular matrix defense against heavy metals cytotoxicity. Identifying the precise glycan sequences that bind a particular heavy metal ion is a key for understanding those ...
  • Synergestic interplay of uronic acid and sulfation composition of heparan sulfate on molecular recognition to activity 
    BHOGE, PREETI RAVINDRA; RAIGAWALI, RAKESH; MARDHEKAR, SANDHYA; ANAND, SAURABH; KIKKERI, RAGHAVENDRA (Elsevier B.V.,, 2023-10)
    Heparan sulfate (HS) is ubiquitous polysaccharide on the surface of all mammalian cells and extracellular matrices. The incredible structural complexity of HS arises from its sulfation patterns and disaccharide compositions, ...

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