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  • Exploring structural features of folded peptide architectures in the construction of nanomaterials 
    Misra, Rajkumar; Reja, Rahi M.; Narendra, Lagumaddepalli V.; George, Gijo; Raghothama, Srinivasarao; GOPI, HOSAHUDYA N. (Royal Society of Chemistry, 2016-06)
    We are reporting the influence of foldamer structures on their self-assembled architectures. In a sharp contrast to the ordered α,γ-hybrid 12-helix obtained from 1 : 1 alternating Aib and γ-Phe, the α,γ-hybrid peptides ...
  • Structural Dimorphism of Achiral α,γ‐Hybrid Peptide Foldamers: Coexistence of 12‐ and 15/17‐Helices 
    Misra, Rajkumar; SASEENDRAN, ABHIJITH; George, Gijo; VEERESH, KURUVA; Raja, K. Muruga Poopathi; Raghothama, Srinivasarao; Hofmann, Hans Jorg; GOPI, HOSAHUDYA N. (Wiley, 2017-03)
    Here, novel 12‐helices in α,γ‐hybrid peptides composed of achiral α‐aminoisobutyric acid (Aib) and 4‐aminoisocaproic acid (Aic, doubly homologated Aib) monomers in 1:1 alternation are reported. The 12‐helices were indicated ...
  • Ambidextrous α,γ‐Hybrid Peptide Foldamers 
    MISRA, RAJKUMAR; George, Gijo; SASEENDRAN, ABHIJITH; Raghothama, Srinivasarao; GOPI, HOSAHUDYA N. (Wiley, 2019-12)
    Molecular chirality is ubiquitous in nature. The natural biopolymers, proteins and DNA, preferred a right‐handed helical bias due to the inherent stereochemistry of the monomer building blocks. Here, we are reporting a ...
  • Structural insight into hybrid peptide epsilon-helices 
    MISRA, RAJKUMAR; George, Gijo; REJA, RAHI M.; DEY, SANJIT; Raghothama, Srinivasarao; GOPI, HOSAHUDYA N. (Royal Society of Chemistry, 2020-02)
    Unique ε-helical organizations (11-helices) from β,γ-hybrid peptides composed of chiral β3-amino acids along with achiral 3,3- or 4,4-dimethyl substituted γ-amino acids are disclosed.
  • Structural Investigation of Hybrid Peptide Foldamers Composed of α‐Dipeptide Equivalent β‐Oxy‐δ5‐amino Acids 
    REJA, RAHI M.; KUMAR, VIVEK; George, Gijo; PATEL, RAJAT; KUMAR, DRGKOPPALU R. PUNEETH; Raghothama, Srinivasarao; GOPI, HOSAHUDYA N. (Wiley, 2020-04)
    Due to their equivalent lengths, δ‐amino acids can serve as surrogates of α‐dipeptides. However, δ‐amino acids with proteinogenic side chains have not been well studied because of synthetic difficulties and because of their ...
  • Proteolytically Stable ααγ-Hybrid Peptides Inhibit the Aggregation and Cytotoxicity of Aβ42 
    KUMAR, D. R. G. KOPPALU R. PUNEETH; NALAWADE, SACHIN A.; PAHAN, SAIKAT; SINGH, MANJEET; Senapati, Dillip K.; ROY, SOUVIK; DEY, SANJIT; TORASKAR, SANDIP U.; Raghothama, Srinivasarao; GOPI, HOSAHUDYA N. (American Chemical Society, 2023-10)
    The recent approval of antibody-based therapy for targeting the clearance of amyloid plaques fuels the research in designing small molecules and peptide inhibitors to target the aggregation of Aβ-peptides. Here, we report ...

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