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Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme

RAJENDRAN, ABINAYA; VAIDYA, KAVERI; Mendoza, Johnny; Bridwell-Rabb, Jennifer; KAMAT, SIDDHESH S. (American Chemical Society, 2020-01)

The metabolic serine hydrolase family is, arguably, one of the largest functional enzyme classes in mammals, including humans, comprising 1-2% of the total proteome. This enzyme family uses a conserved nucleophilic serine ...
Identification of sequence determinants for the ABHD14 enzymes

VAIDYA, KAVERI; RODRIGUES, GOLDING; GUPTA, SONALI; Devarajan, Archit; YEOLEKAR, MIHIKA; MADHUSUDHAN, M. S.; KAMAT, SIDDHESH S. (Wiley, 2023-11)

Over the course of evolution, enzymes have developed remarkable functional diversity in catalyzing important chemical reactions across various organisms, and understanding how new enzyme functions might have evolved remains ...

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