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  • Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity 
    NIRWAN, NEHA; SINGH, PRATIMA; MISHRA, GYANA GOURAB; Johnson, Christopher M; Szczelkun, Mark D; Inoue, Katsuaki; Vinothkumar, Kutti R.; KAYARAT, SAIKRISHNAN (Oxford University Press, 2019-01)
    McrBC is one of the three modification-dependent restriction enzymes encoded by the Escherichia coli K12 chromosome. Amongst restriction enzymes, McrBC and its close homologues are unique in employing the AAA+ domain for ...
  • Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC 
    NIRWAN, NEHA; Itoh, Yuzuru; SINGH, PRATIMA; BANDYOPADHYAY, SUTIRTHA; Vinothkumar, Kutti R.; Amunts, Alexey; KAYARAT, SAIKRISHNAN (Nature Publishing Group, 2019-07)
    The AAA+ GTPase McrB powers DNA cleavage by the endonuclease McrC. The GTPase itself is activated by McrC. The architecture of the GTPase and nuclease complex, and the mechanism of their activation remained unknown. Here, ...

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