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Maternal malnutrition and anaemia in India: dysregulations leading to the ‘thin-fat’ phenotype in newborns

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dc.contributor.author Pandit, Prachi en_US
dc.contributor.author GALANDE, SANJEEV en_US
dc.contributor.author Iris, François en_US
dc.date.accessioned 2021-10-18T10:30:51Z
dc.date.available 2021-10-18T10:30:51Z
dc.date.issued 2021-10 en_US
dc.identifier.citation Journal of Nutritional Science, 10, e91. en_US
dc.identifier.issn 2048-6790 en_US
dc.identifier.issn 2048-6790 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/6320
dc.identifier.uri https://doi.org/10.1017/jns.2021.83 en_US
dc.description.abstract Maternal and child malnutrition and anaemia remain the leading factors for health loss in India. Low birth weight (LBW) offspring of women suffering from chronic malnutrition and anaemia often exhibit insulin resistance and infantile stunting and wasting, together with increased risk of developing cardiometabolic disorders in adulthood. The resulting self-perpetuating and highly multifactorial disease burden cannot be remedied through uniform dietary recommendations alone. To inform approaches likely to alleviate this disease burden, we implemented a systems-analytical approach that had already proven its efficacy in multiple published studies. We utilised previously published qualitative and quantitative analytical results of rural and urban field studies addressing maternal and infantile metabolic and nutritional parameters to precisely define the range of pathological phenotypes encountered and their individual biological characteristics. These characteristics were then integrated, via extensive literature searches, into metabolic and physiological mechanisms to identify the maternal and foetal metabolic dysregulations most likely to underpin the ‘thin-fat’ phenotype in LBW infants and its associated pathological consequences. Our analyses reveal hitherto poorly understood maternal nutrition-dependent mechanisms most likely to promote and sustain the self-perpetuating high disease burden, especially in the Indian population. This work suggests that it most probably is the metabolic consequence of ‘ill-nutrition’ – the recent and rapid dietary shifts to high salt, high saturated fats and high sugar but low micronutrient diets – over an adaptation to ‘thrifty metabolism’ which must be addressed in interventions aiming to significantly alleviate the leading risk factors for health deterioration in India. en_US
dc.language.iso en en_US
dc.publisher Cambridge University Press en_US
dc.subject Anaemia en_US
dc.subject Low birth weight en_US
dc.subject Malnutrition en_US
dc.subject Pathological mechanisms en_US
dc.subject Physiological programming en_US
dc.subject 2021-OCT-WEEK1 en_US
dc.subject TOC-OCT-2021 en_US
dc.subject 2021 en_US
dc.title Maternal malnutrition and anaemia in India: dysregulations leading to the ‘thin-fat’ phenotype in newborns en_US
dc.type Article en_US
dc.contributor.department Dept. of Biology en_US
dc.identifier.sourcetitle Journal of Nutritional Science en_US
dc.publication.originofpublisher Foreign en_US


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