Digital Repository

The rates of stem cell division determine the cell cycle lengths of its lineage

Show simple item record Gadre, Purna en_US Nitsure, Nitin en_US MAZUMDAR, DEBASMITA en_US Gupta, Samir en_US Ray, Krishanu en_US 2021-12-31T07:40:34Z 2021-12-31T07:40:34Z 2021-11 en_US
dc.identifier.citation iSicence, 24(11), 103232. en_US
dc.identifier.issn 2589-0042 en_US
dc.identifier.uri en_US
dc.description.abstract Adult stem cells and their transit-amplifying progeny alter their proliferation rates to maintain tissue homeostasis. To test how the division rates of stem cells and transit-amplifying progeny affect tissue growth and differentiation, we developed a computation strategy that estimates the average cell-cycle lengths (lifespans) of germline stem cells and their progeny from fixed-tissue demography in the Drosophila testis. Analysis of the wild-type data using this method indicated that during the germline transit-amplification, the cellular lifespans extend by nearly 1.3-fold after the first division and shrink by about 2-folds after the second division. Cell-autonomous perturbations of the stem cell lifespan accordingly altered the lifespans of successive transit-amplifying stages. Remarkably, almost 2-fold alterations in the lifespans of stem cells and their immediate daughters did not affect the subsequent differentiation. The results indicate that the early germline division rates can adjust the following division rates and the onset of differentiation. en_US
dc.language.iso en en_US
dc.publisher Elsevier B.V. en_US
dc.subject Cell biology en_US
dc.subject Stem cells research en_US
dc.subject Bioinformatics en_US
dc.subject 2021-DEC-WEEK4 en_US
dc.subject TOC-DEC-2021 en_US
dc.subject 2021 en_US
dc.title The rates of stem cell division determine the cell cycle lengths of its lineage en_US
dc.type Article en_US
dc.contributor.department Dept. of Biology en_US
dc.identifier.sourcetitle iSicence en_US
dc.publication.originofpublisher Foreign en_US

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Repository

Advanced Search


My Account