Enhancing cellular sulfane sulfur through β-glycosidase-activated persulfide donors: mechanistic insights and oxidative stress mitigation

CHAKRAPANI, HARINATH; BORA, PRERONA; SATHIAN, MANJIMA B.

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dc.contributor.author	BORA, PRERONA	en_US
dc.contributor.author	SATHIAN, MANJIMA B.	en_US
dc.contributor.author	CHAKRAPANI, HARINATH	en_US
dc.date.accessioned	2022-03-30T04:09:34Z
dc.date.available	2022-03-30T04:09:34Z
dc.date.issued	2022-03	en_US
dc.identifier.citation	Chemical Communications, 58(18), 2987-2990.	en_US
dc.identifier.issn	1359-7345	en_US
dc.identifier.issn	1364-548X	en_US
dc.identifier.uri	https://doi.org/10.1039/D1CC07162A	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/6634
dc.description.abstract	Sulfane sulfur species such as persulfides and polysulfides along with hydrogen sulfide protect cells from oxidative stress and are key members of the cellular antioxidant pool. Here, we report perthiocarbamate-based prodrugs that are cleaved by β-glycosidases to produce persulfide and relatively innocuous byproducts. The β-glucosidase-activated persulfide donor enhances cellular sulfane sulfur and protects cells against lethality induced by elevated reactive oxygen species (ROS).	en_US
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.subject	Hydrogen-Sulfide	en_US
dc.subject	Fluorescent-Probes	en_US
dc.subject	Carbonyl Sulfide	en_US
dc.subject	Drug-Delivery	en_US
dc.subject	Glucosidase	en_US
dc.subject	2022-MAR-WEEK2	en_US
dc.subject	TOC-MAR-2022	en_US
dc.subject	2022	en_US
dc.title	Enhancing cellular sulfane sulfur through β-glycosidase-activated persulfide donors: mechanistic insights and oxidative stress mitigation	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Chemical Communications	en_US
dc.publication.originofpublisher	Foreign	en_US