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Porphyrin in Prebiotic Catalysis: Ascertaining a Route for the Emergence of Early Metalloporphyrins

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dc.contributor.author DAGAR, SHIKHA en_US
dc.contributor.author SARKAR, SUSOVAN en_US
dc.contributor.author RAJAMANI, SUDHA en_US
dc.date.accessioned 2022-03-30T04:09:52Z
dc.date.available 2022-03-30T04:09:52Z
dc.date.issued 2022-04 en_US
dc.identifier.citation ChemBioChem, 23(8), e202200013. en_US
dc.identifier.issn 1439-4227 en_US
dc.identifier.issn 1439-7633 en_US
dc.identifier.uri https://doi.org/10.1002/cbic.202200013 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/6652
dc.description.abstract Metal ions are known to catalyze certain prebiotic reactions. However, the transition from metal ions to extant metalloenzymes remains unclear. Porphyrins are found ubiquitously in the catalytic core of many ancient metalloenzymes. In this study, we evaluated the influence of porphyrin-based organic scaffold, on the catalysis, emergence and putative molecular evolution of prebiotic metalloporphyrins. We studied the effect of porphyrins on the transition metal ion-mediated oxidation of hydroquinone (HQ). We report a change in the catalytic activity of the metal ions in the presence of porphyrin. This was observed to be facilitated by the coordination between metal ions and porphyrins or by the formation of non-coordinated complexes. The metal-porphyrin complexes also oxidized NADH, underscoring its versatility at oxidizing more than one substrate. Our study highlights the selective advantage that some of the metal ions would have had in the presence of porphyrin, underscoring their role in shaping the evolution of protometalloenzymes. en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.subject Biology en_US
dc.subject 2022-MAR-WEEK3 en_US
dc.subject TOC-MAR-2022 en_US
dc.subject 2022 en_US
dc.title Porphyrin in Prebiotic Catalysis: Ascertaining a Route for the Emergence of Early Metalloporphyrins en_US
dc.type Article en_US
dc.contributor.department Dept. of Biology en_US
dc.identifier.sourcetitle ChemBioChem en_US
dc.publication.originofpublisher Foreign en_US


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