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Development of Photoactivatable Ion Transporters for Photodynamic Anticancer Therapy

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dc.contributor.advisor TALUKDAR, PINAKI en_US
dc.contributor.author BANZAL, KSHITIJ V en_US
dc.date.accessioned 2022-05-12T09:54:49Z
dc.date.available 2022-05-12T09:54:49Z
dc.date.issued 2022-05
dc.identifier.citation 51 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/6872
dc.description.abstract The interest in developing small molecule-based synthetic ion transporters has been tremendous in recent times in supramolecular chemistry, providing a plethora of studies mainly focusing on the transport of chloride ions. However, this potential is not realized entirely due to the uninhibited action of such transporters in biological systems. Hence, external stimulus, especially light, helps in providing the required specificity to the ion transport system in the form of photo-irradiative ion transporters. Herein, we report a series of tolane-based ion-transporters and o-nitrobenzyl linked photo-cleavable pro-carrier molecules, where the former can transport anion via the antiport process confirmed from the valinomycin assay. Compound1bshowed the highest transport efficiency among the congeners across EYPC−LUVs⊃HPTS, and the synthesis and characterization of the pro-carrier molecule of that derivative were carried out. Ion selectivity studies reveal that compound 1b has the highest transport efficiency towards Cl− ion. The photo-cleavable property of compound 1' helps in enabling the selective photo-controlled release of the active carrier 1b, which can specifically initiate chloride-mediated apoptosis in cancer cells over healthy cells. en_US
dc.language.iso en_US en_US
dc.subject ion transport en_US
dc.subject anion transport en_US
dc.subject chloride transport en_US
dc.subject ion transporter en_US
dc.subject anion transporter en_US
dc.subject chloride transporter en_US
dc.subject HPTS assay en_US
dc.subject Lucigenin en_US
dc.subject Lucigenin assay en_US
dc.subject Valinomycin en_US
dc.subject Valinomycin assay en_US
dc.subject Calcein assay en_US
dc.subject NMR Binding en_US
dc.subject NMR Binding Studies en_US
dc.subject supramolecular chemistry en_US
dc.subject tolane-based ion-transporters en_US
dc.subject o-nitrobenzyl en_US
dc.subject photo-cleavable pro-carrier en_US
dc.subject Photo-Cleavable Ion Transporters en_US
dc.subject photolabile protecting group en_US
dc.subject Photo-activation en_US
dc.subject Photo-Activatable Ion Transporters en_US
dc.title Development of Photoactivatable Ion Transporters for Photodynamic Anticancer Therapy en_US
dc.type Thesis en_US
dc.type.degree BS-MS en_US
dc.contributor.department Dept. of Chemistry en_US
dc.contributor.registration 20171174 en_US


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  • MS THESES [1705]
    Thesis submitted to IISER Pune in partial fulfilment of the requirements for the BS-MS Dual Degree Programme/MSc. Programme/MS-Exit Programme

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