Digital Repository

A single-molecule stochastic theory of protein-ligand binding in the presence of multiple unfolding/folding and ligand binding pathways

Show simple item record

dc.contributor.author SINGH, DIVYA en_US
dc.contributor.author CHAUDHURY, SRABANTI en_US
dc.date.accessioned 2022-05-23T10:39:22Z
dc.date.available 2022-05-23T10:39:22Z
dc.date.issued 2022-06 en_US
dc.identifier.citation Biophysical Chemistry, 285, 106803. en_US
dc.identifier.issn 0301-4622 en_US
dc.identifier.issn 1873-4200 en_US
dc.identifier.uri https://doi.org/10.1016/j.bpc.2022.106803 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/6980
dc.description.abstract Protein folding is a biophysical process by which a protein chain is translated to its native (folded) structure through several intermediate states such that the folded conformation becomes biologically functional. This folded protein can again exist in multiple conformations in its native state and its intrinsic conformational fluctuations are responsible for the protein-ligand recognition and binding to form a specific complex. In this study, we introduce an exactly solvable kinetic model based on a discrete stochastic approach to study the protein-ligand binding by taking into account an arbitrary number of the transient intermediates between the unfolded and the native folded state of the protein. We also examine the conformational fluctuations in the folded state explicitly. The dynamic properties of the system are explicitly evaluated to understand the role of short-lived conformations in the process of protein folding and also conformational fluctuations existing in the folded state of the protein. en_US
dc.language.iso en en_US
dc.publisher Elsevier B.V. en_US
dc.subject Protein folding en_US
dc.subject Master equation en_US
dc.subject Stochastic theory en_US
dc.subject Randomness parameter en_US
dc.subject 2022-MAY-WEEK2 en_US
dc.subject TOC-MAY2022 en_US
dc.subject 2022 en_US
dc.title A single-molecule stochastic theory of protein-ligand binding in the presence of multiple unfolding/folding and ligand binding pathways en_US
dc.type Article en_US
dc.contributor.department Dept. of Chemistry en_US
dc.identifier.sourcetitle Biophysical Chemistry en_US
dc.publication.originofpublisher Foreign en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Repository


Advanced Search

Browse

My Account