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Structure-editing of nucleic acids for selective targeting of RNA

Show simple item record Kumar, Vaijayanti A. en_US GANESH, K. N en_US 2022-06-13T04:29:00Z 2022-06-13T04:29:00Z 2007-01 en_US
dc.identifier.citation Current Topics in Medicinal Chemistry, 7(7), 715-726. en_US
dc.identifier.issn 1568-0266 en_US
dc.identifier.issn 1873-4294 en_US
dc.identifier.uri en_US
dc.description.abstract The synthesis of backbone-modified nucleic acids has been an area of very intense research over the last two decades. The main reason for this research activity is the instability of nucleic acid based drugs in the intracellular conditions. Changes in the sugar-phosphate backbone invariably bring about the changes in the complementation properties of the nucleic acids. The naturally occurring deoxyribose- (DNA) and ribose (RNA) sugar-phosphate backbones are endowed with considerable differences in their binding affinities towards themselves. This occurs because of the different sugar conformations prevalent in DNA and RNA and the subtle structural changes accruing from these in hydrogen bonding, base-stacking interactions and hydration of major/minor grooves. The six-atom phosphodiester linkages and pentose-sugars give immense opportunities for chemical modifications that lead to several backbone-modified nucleic acid structures. This article is focused on such modifications that impart RNA-selective binding properties to the modified nucleic acid mimics and the rationale behind the said selectivity. It is found that the six-atom sugar-phosphate backbone could be replaced by either one-atom extended or one-atom edited repeating units, leading to the folded or extended geometries to maintain the internucleoside distance-complementarity. Other important contributions come from electronegativity of the substituent groups, hydration in the major/minor groove, base stacking etc. en_US
dc.language.iso en en_US
dc.publisher Bentham Science Publishers en_US
dc.subject Oligonucleotides en_US
dc.subject Antisense agent en_US
dc.subject Enantio-DNA sequences en_US
dc.subject N-type sugar ring en_US
dc.subject Phosphoramidates en_US
dc.subject 2007 en_US
dc.title Structure-editing of nucleic acids for selective targeting of RNA en_US
dc.type Article en_US
dc.contributor.department Dept. of Chemistry en_US
dc.identifier.sourcetitle Current Topics in Medicinal Chemistry en_US
dc.publication.originofpublisher Foreign en_US

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