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Dehydrogenative Intramolecular Macrolactonization of Dihydroxy Compounds Using Ru-MACHO Catalyst

Dehydrogenative Intramolecular Macrolactonization of Dihydroxy Compounds Using Ru-MACHO Catalyst

JAMDADE, AKASH BANDU; SUTAR, DASHRAT VISHAMBAR; GNANAPRAKASAM, BOOPATHY
URI: https://doi.org/10.1021/acs.orglett.2c01617
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7249
Date: 2022-06


Abstract:

Herein, we have developed a new approach for the synthesis of 11 to 21-membered macrolactones via intramolecular dehydrogenative coupling of primary alcohols by using Ru-MACHO as a catalyst and Cs2CO3 as a base. This protocol generated 11–21-ring-sized macrocycles (26 derivatives), free from an external oxidant or an additive, eliminating stoichiometric reagents and producing only hydrogen as a byproduct.

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