Digital Repository

pH-responsive self-assembled compartments as tuneable model protocellular membrane systems

Show simple item record

dc.contributor.author SARKAR, SUSOVAN en_US
dc.contributor.author DAGAR, SHIKHA en_US
dc.contributor.author LAHIRI, KUSHAN en_US
dc.contributor.author RAJAMANI, SUDHA en_US
dc.date.accessioned 2022-08-30T08:49:26Z
dc.date.available 2022-08-30T08:49:26Z
dc.date.issued 2022-12 en_US
dc.identifier.citation ChemBioChem, 23(24), e202200371. en_US
dc.identifier.issn 1439-7633 en_US
dc.identifier.uri https://doi.org/10.1002/cbic.202200371 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7338
dc.description.abstract Prebiotically plausible single-chain amphiphiles are enticing as model protocellular compartments to study the emergence of cellular life owing to their self-assembling properties. Here, we investigated the self-assembly behaviour of mono-N-dodecyl phosphate (DDP) and mixed systems of DDP with 1-dodecanol (DDOH) at varying pH conditions. Membranes composed of DDP showed pH-responsive vesicle formation in a wide range of pH with a low critical bilayer concentration (CBC). Further, the addition of DDOH to DDP membrane system enhanced vesicle formation and stability in alkaline pH regimes. We also compared the high-temperature behaviour of DDP and DDP:DDOH membranes with conventional fatty acid membranes. Both, DDP and DDP:DDOH mixed membranes possess packing that is similar to decanoic acid membrane. However, the micropolarity of these systems are similar to phospholipid membranes. Finally, the pH-dependent modulation of different phospholipid membranes doped with DDP was also demonstrated to engineer tuneable membranes with potential translational implications. en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.subject Chemistry en_US
dc.subject 2022-AUG-WEEK5 en_US
dc.subject TOC-AUG-2022 en_US
dc.subject 2022 en_US
dc.title pH-responsive self-assembled compartments as tuneable model protocellular membrane systems en_US
dc.type Article en_US
dc.contributor.department Dept. of Biology en_US
dc.identifier.sourcetitle ChemBioChem en_US
dc.publication.originofpublisher Foreign en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Repository


Advanced Search

Browse

My Account