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pH-responsive self-assembled compartments as tuneable model protocellular membrane systems

Show simple item record SARKAR, SUSOVAN en_US DAGAR, SHIKHA en_US LAHIRI, KUSHAN en_US RAJAMANI, SUDHA en_US 2022-08-30T08:49:26Z 2022-08-30T08:49:26Z 2022-12 en_US
dc.identifier.citation ChemBioChem, 23(24), e202200371. en_US
dc.identifier.issn 1439-7633 en_US
dc.identifier.uri en_US
dc.description.abstract Prebiotically plausible single-chain amphiphiles are enticing as model protocellular compartments to study the emergence of cellular life owing to their self-assembling properties. Here, we investigated the self-assembly behaviour of mono-N-dodecyl phosphate (DDP) and mixed systems of DDP with 1-dodecanol (DDOH) at varying pH conditions. Membranes composed of DDP showed pH-responsive vesicle formation in a wide range of pH with a low critical bilayer concentration (CBC). Further, the addition of DDOH to DDP membrane system enhanced vesicle formation and stability in alkaline pH regimes. We also compared the high-temperature behaviour of DDP and DDP:DDOH membranes with conventional fatty acid membranes. Both, DDP and DDP:DDOH mixed membranes possess packing that is similar to decanoic acid membrane. However, the micropolarity of these systems are similar to phospholipid membranes. Finally, the pH-dependent modulation of different phospholipid membranes doped with DDP was also demonstrated to engineer tuneable membranes with potential translational implications. en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.subject Chemistry en_US
dc.subject 2022-AUG-WEEK5 en_US
dc.subject TOC-AUG-2022 en_US
dc.subject 2022 en_US
dc.title pH-responsive self-assembled compartments as tuneable model protocellular membrane systems en_US
dc.type Article en_US
dc.contributor.department Dept. of Biology en_US
dc.identifier.sourcetitle ChemBioChem en_US
dc.publication.originofpublisher Foreign en_US

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