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Structural Control of Peptide Nucleic Acid Rotamers: Aza-PNA and Optical Properties of Gemdimethyl PNA, Bimodal PNA Monomers and Oligomers
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| dc.contributor.advisor | GANESH, KRISHNA N. | en_US |
| dc.contributor.author | SHIRAJ, ABDUL | en_US |
| dc.date.accessioned | 2022-10-17T11:53:59Z | |
| dc.date.available | 2022-10-17T11:53:59Z | |
| dc.date.issued | 2022-06 | en_US |
| dc.identifier.citation | 315 | en_US |
| dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7398 | |
| dc.description | This chapter gives an overview of DNA/RNA duplex, triplex and tetraplex structure, chemically modified DNA and Peptide nucleic acid. Synthetically modified oligonucleotide (ODNs) of DNA and RNA are capable of forming Watson-Crick hydrogen bonded duplex between the two complementary strands as natural DNA. Polypyrimidine sequences of DNA/RNA oligomers are capable of forming triplexes by combination of Watson-crick and Hoogsteen hydrogen bonding among the three composed strands. The specificity in complementary base pairing to forming stable duplexes and triplexes make synthetic DNA an ideal candidate to suppress undesirable genes and is the basis of new medicinal chemistry concept of antigene and antisense therapy. | en_US |
| dc.description.abstract | The thesis entitled “Structural control of Peptide Nucleic Acid (PNA) rotamers and their fluorescence properties: aza-PNA, gemdimethyl G-PNA and Cα(S)-bm PNA monomers and oligomers” describes studies done on the synthesis, characterisation and rotamer study of novel aza-PNA monomers, α/β-gemdimethyl guanine PNA, Cα(S)-(acetamido)-bm PNA monomers and oligomers. The effect of intramolecular H-bonding in Cα-NH (aza-PNA) and gem-dimethyl substitution induced conformational constraint on rotamer selectivity and the fluorescence properties are explored in this work. The thesis is presented in five chapters. | en_US |
| dc.description.sponsorship | CSIR , IISER-Pune | en_US |
| dc.language.iso | en | en_US |
| dc.subject | Chemistry | en_US |
| dc.title | Structural Control of Peptide Nucleic Acid Rotamers: Aza-PNA and Optical Properties of Gemdimethyl PNA, Bimodal PNA Monomers and Oligomers | en_US |
| dc.type | Thesis | en_US |
| dc.description.embargo | one year | en_US |
| dc.type.degree | Ph.D | en_US |
| dc.contributor.department | Dept. of Chemistry | en_US |
| dc.contributor.registration | 20163469 | en_US |
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PhD THESES [603]
Thesis submitted to IISER Pune in partial fulfilment of the requirements for the degree of Doctor of Philosophy