Aza-PNA: Engineering E-Rotamer Selectivity Directed by Intramolecular H-bonding

SHIRAJ, ABDUL; GANESH, KRISHNA N.; Ramabhadran, Raghunath O.

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dc.contributor.author	SHIRAJ, ABDUL	en_US
dc.contributor.author	Ramabhadran, Raghunath O.	en_US
dc.contributor.author	GANESH, KRISHNA N.	en_US
dc.date.accessioned	2022-12-28T09:21:55Z
dc.date.available	2022-12-28T09:21:55Z
dc.date.issued	2022-10	en_US
dc.identifier.citation	Organic Letters, 24(40), 7421–7427.	en_US
dc.identifier.issn	1523-7060	en_US
dc.identifier.issn	1523-7052	en_US
dc.identifier.uri	https://doi.org/10.1021/acs.orglett.2c02993	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7542
dc.description.abstract	The replacement of α(CH2) by NH in monomers of standard aeg PNA and its homologue β-ala PNA leads to respective aza-PNA monomers (1 and 2) in which the NαH can form either an 8-membered H-bonded ring with folding of the backbone (DMSO and water) or a 5-membered NαH─αCO (water) to stabilize E-type rotamers. Such aza-PNA oligomers with exclusive E rotamers and intraresidue backbone H-bonding can modulate its DNA/RNA binding and assembling properties.	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	Amides	en_US
dc.subject	Chemical structure	en_US
dc.subject	Nuclear magnetic resonance spectroscopy	en_US
dc.subject	Organic compounds	en_US
dc.subject	Solvents	en_US
dc.subject	2022-DEC-WEEK3	en_US
dc.subject	TOC-DEC-2022	en_US
dc.subject	2022	en_US
dc.title	Aza-PNA: Engineering E-Rotamer Selectivity Directed by Intramolecular H-bonding	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Organic Letters	en_US
dc.publication.originofpublisher	Foreign	en_US