dc.contributor.author |
CHAKRABORTY, SAPTASHWA |
en_US |
dc.contributor.author |
MISHRA, BIJOYANANDA |
en_US |
dc.contributor.author |
DAS, PRATIM KUMAR |
en_US |
dc.contributor.author |
PASARI, SANDIP |
en_US |
dc.contributor.author |
HOTHA, SRINIVAS |
en_US |
dc.date.accessioned |
2023-01-20T05:39:09Z |
|
dc.date.available |
2023-01-20T05:39:09Z |
|
dc.date.issued |
2023-02 |
en_US |
dc.identifier.citation |
Angewandte Chemie International Edition, 62(6), e202214167. |
en_US |
dc.identifier.issn |
1433-7851 |
en_US |
dc.identifier.issn |
1521-3773 |
en_US |
dc.identifier.uri |
https://doi.org/10.1002/anie.202214167 |
en_US |
dc.identifier.uri |
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7567 |
|
dc.description.abstract |
The synthesis of N-glycosides from stable glycosyl donors in a catalytic fashion is still challenging, though they exist ubiquitously in DNA, RNA, glycoproteins, and other biological molecules. Herein, silver-assisted gold-catalyzed activation of alkynyl glycosyl carbonate donors is shown to be a versatile approach for the synthesis of purine and pyrimidine nucleosides, asparagine glycosides and quinolin-2-one N-glycosides. Thus synthesized nucleosides were subjected to the oxidation–reduction sequence for the conversion of Ribf- into Araf- nucleosides, giving access to nucleosides that are otherwise difficult to synthesize. Furthermore, the protocol is demonstrated to be suitable for the synthesis of 2’-modified nucleosides in a facile manner. Direct attachment of an asparagine-containing dipeptide to the glucopyranose and subsequent extrapolation to afford the dipeptide disaccharide unit of chloroviruses is yet another facet of this endeavor. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Wiley |
en_US |
dc.subject |
Glycosylation |
en_US |
dc.subject |
Homogeneous Catalysis |
en_US |
dc.subject |
N-Glycosides |
en_US |
dc.subject |
Nucleosides |
en_US |
dc.subject |
Transition-Metal Catalysis |
en_US |
dc.subject |
2023 |
en_US |
dc.subject |
TOC-JAN-2023 |
|
dc.subject |
2023-JAN-WEEK3 |
|
dc.title |
Synthesis of N-Glycosides by Silver-Assisted Gold Catalysis |
en_US |
dc.type |
Article |
en_US |
dc.contributor.department |
Dept. of Chemistry |
en_US |
dc.identifier.sourcetitle |
Angewandte Chemie International Edition |
en_US |
dc.publication.originofpublisher |
Foreign |
en_US |