Abstract:
Heparan sulfate is extracellular irregularly sulfonated macromolecules that influence
the activities of various proteins on the cell surfaces. Hence, obtaining well-defined
sequences of heparan sulfate is a huge challenging to understand structurefunctional
activities. Herein, we present the design and synthesis of heparan sulfate
analogs that decipher the role of sulfated patterns of heparan sulfate in biological
structure and functions. To achieve this, I have synthesized glucosamine building
block in such a way as to generate a library of sulfated-glucosamine patterns with
amine linker. These molecules will be immobilization on microarray slides to study
lectin, cytokines and chemokines binding affinities and its subsequent biological
responses.
