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Synthesis of MTX-Capped Octasacchride & Metal-Free Activation of Carbonate Donor

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dc.contributor.advisor HOTHA, SRINIVAS
dc.contributor.author PRASAD, KAMESHWAR
dc.date.accessioned 2023-11-08T09:12:33Z
dc.date.available 2023-11-08T09:12:33Z
dc.date.issued 2023-07
dc.identifier.citation 246 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/8262
dc.description.abstract Title: Synthesis of MTX-Capped Octasaccharide & Metal-Free Activation of Carbonate Donor Kingdom of life on the earth contains four types of macromolecules: proteins, lipids, nucleic acid, and carbohydrates. Carbohydrate based polymers are called glycans. However, when it is conjugated to any aglycone residue is called glycoconjugate. Glycans and their glycoconjugates are present in every cell of the kingdom of life and mammals, are involved in a myriad of biological functions, these functions are broadly categorized into three categories mainly: (i) structural and modulatory functions, (ii) specific recognition by other molecules, and (iii) molecular mimicry of host glycans. However, extraction of homogenous glycans and glycoconjugate from nature is a daunting task. Hence, chemical glycosylation is one of the best alternate approaches to obtain these glycans and glycoconjugates. In this regard, our laboratory has developed an alkyne carbonate-based donor which was activated by gold and silver salt (B. Mishra, M. Neralkar, S. Hotha, Angew. Chem. Int. Ed. 2016, 55, 7786.), which was stable and high yielding glycosylation method. In this thesis, I have explored alkyne carbonate-based donor for the chemical synthesis of methylthioxylose (MTX) octasaccharide capping motif of lipoarabinomannan (LAM) present in Mycobacterium tuberculosis exploiting [2+(4+2)] coupling strategy. Moreover, metal-free activation of alkyne carbonate donor and its utility in the synthesis of O-glycoside, nucleosides, and synthesis of pentasaccharide Repeating Unit of Klebsiella Pneumoniae (O-3-Antigen) is discussed. en_US
dc.description.sponsorship CSIR New-Delhi en_US
dc.language.iso en_US en_US
dc.subject Carbohydrate Synthesis en_US
dc.subject MTX-Capped Octasaccharide en_US
dc.subject Metal-Free Acivation en_US
dc.subject Nucleoside Synthesis en_US
dc.subject Klebsiella pneumoniae O-3 Antigen en_US
dc.subject Pentasaccharide en_US
dc.title Synthesis of MTX-Capped Octasacchride & Metal-Free Activation of Carbonate Donor en_US
dc.type Thesis en_US
dc.description.embargo 1 Year en_US
dc.type.degree Ph.D en_US
dc.contributor.department Dept. of Chemistry en_US
dc.contributor.registration 20183601 en_US


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  • PhD THESES [590]
    Thesis submitted to IISER Pune in partial fulfilment of the requirements for the degree of Doctor of Philosophy

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