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Exploring the role of heterogeneity in quorum sensing cells: a discrete state stochastic approach

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dc.contributor.author JANGID, PANKAJ en_US
dc.contributor.author CHAUDHURY, SRABANTI en_US
dc.date.accessioned 2024-02-05T07:27:17Z
dc.date.available 2024-02-05T07:27:17Z
dc.date.issued 2023-09 en_US
dc.identifier.citation Journal of Statistical Mechanics: Theory and Experiment, 2023, 093501. en_US
dc.identifier.issn 1742-5468 en_US
dc.identifier.uri https://doi.org/10.1088/1742-5468/acf7ba en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/8460
dc.description.abstract Quorum sensing (QS) is a bacterial communication process in which cells detect the local environment and collectively activate gene expression. The transcriptional activator (LuxR) for these genes has a specific allosteric site where the autoinducer (AHL) can bind and turn the activator on. At the single-cell level, the response to gene activation is poorly coordinated among the QS population which leads to heterogeneity in an isogenic population. The paper presents a theoretical framework that uses a discrete-state stochastic approach to address the issue of heterogeneity in the context of DNA target search processes in QS cells and takes into account the relevant physical–chemical processes. This minimal model allows us to understand the molecular mechanisms of the protein target search in the context of cell heterogeneity, and evaluate the analytical expression of the protein search times for the targets on DNA. Specifically, it is shown that the variations in AHL and LuxR binding rates, arising from the asymmetric distribution of LuxR proteins in the cell population, can cause significant variations in the target search on the DNA. It is also found that the intrinsic heterogeneity in the cell population can affect the average search time and this in turn depends on the AHL and LuxR binding rates. Proposed theoretical results have been validated by Monte Carlo simulations. en_US
dc.language.iso en en_US
dc.publisher IOP Publishing en_US
dc.subject Quorum sensing en_US
dc.subject Protein-DNA interaction en_US
dc.subject Heterogeneity en_US
dc.subject Stochastic process en_US
dc.subject Master equation en_US
dc.subject 2023 en_US
dc.title Exploring the role of heterogeneity in quorum sensing cells: a discrete state stochastic approach en_US
dc.type Article en_US
dc.contributor.department Dept. of Chemistry en_US
dc.identifier.sourcetitle Journal of Statistical Mechanics: Theory and Experiment en_US
dc.publication.originofpublisher Foreign en_US


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