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Lysophosphatidylserine: A Signaling Lipid with Implications in Human Diseases

Show simple item record CHAKRABORTY, ARNAB en_US KAMAT, SIDDHESH S. en_US 2024-04-24T05:45:27Z 2024-04-24T05:45:27Z 2024-04 en_US
dc.identifier.citation Chemical Reviews en_US
dc.identifier.issn 0009-2665 en_US
dc.identifier.issn 1520-6890 en_US
dc.identifier.uri en_US
dc.description.abstract Lysophosphatidylserine (lyso-PS) has emerged as yet another important signaling lysophospholipid in mammals, and deregulation in its metabolism has been directly linked to an array of human autoimmune and neurological disorders. It has an indispensable role in several biological processes in humans, and therefore, cellular concentrations of lyso-PS are tightly regulated to ensure optimal signaling and functioning in physiological settings. Given its biological importance, the past two decades have seen an explosion in the available literature toward our understanding of diverse aspects of lyso-PS metabolism and signaling and its association with human diseases. In this Review, we aim to comprehensively summarize different aspects of lyso-PS, such as its structure, biodistribution, chemical synthesis, and SAR studies with some synthetic analogs. From a biochemical perspective, we provide an exhaustive coverage of the diverse biological activities modulated by lyso-PSs, such as its metabolism and the receptors that respond to them in humans. We also briefly discuss the human diseases associated with aberrant lyso-PS metabolism and signaling and posit some future directions that may advance our understanding of lyso-PS-mediated mammalian physiology. en_US
dc.language.iso en en_US
dc.publisher American Chemical Society en_US
dc.subject Central nervous system en_US
dc.subject Lipids en_US
dc.subject Metabolism en_US
dc.subject Peptides and proteins en_US
dc.subject Rodent models en_US
dc.subject 2024 en_US
dc.subject 2024-APR-WEEK1 en_US
dc.subject TOC-APR-2024 en_US
dc.title Lysophosphatidylserine: A Signaling Lipid with Implications in Human Diseases en_US
dc.type Article en_US
dc.contributor.department Dept. of Biology en_US
dc.identifier.sourcetitle Chemical Reviews en_US
dc.publication.originofpublisher Foreign en_US

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