dc.contributor.author |
SALUNKE, SWATI BANSI |
en_US |
dc.contributor.author |
Save, Shreyada N. |
en_US |
dc.contributor.author |
ROY, NAVEEN J. |
en_US |
dc.contributor.author |
NAOREM, RONEDY |
en_US |
dc.contributor.author |
Sharma, Shilpy |
en_US |
dc.contributor.author |
TALUKDAR, PINAKI |
en_US |
dc.date.accessioned |
2024-06-21T05:41:29Z |
|
dc.date.available |
2024-06-21T05:41:29Z |
|
dc.date.issued |
2024-05 |
en_US |
dc.identifier.citation |
Organic & Biomolecular Chemistry. |
en_US |
dc.identifier.issn |
1477-0520 |
en_US |
dc.identifier.issn |
1477-0539 |
en_US |
dc.identifier.uri |
https://doi.org/10.1039/D4OB00554F |
en_US |
dc.identifier.uri |
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/8995 |
|
dc.description.abstract |
Few synthetic ion transporters have been reported incorporating indole as the core moiety. We have developed a novel bisindole-based transporter capable of efficient transmembrane anion antiport. This system induced cytotoxicity in MCF-7 breast cancer cells via chloride ion homeostasis disruption and the associated ROS generation, mitochondrial membrane depolarization, and lysosomal deacidification. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Royal Society of Chemistry |
en_US |
dc.subject |
Binding protein |
en_US |
dc.subject |
Prodigiosin |
en_US |
dc.subject |
Indole |
en_US |
dc.subject |
Receptors |
en_US |
dc.subject |
Carbazole |
en_US |
dc.subject |
Chloride |
en_US |
dc.subject |
2024 |
en_US |
dc.subject |
2024-JUN-WEEK1 |
en_US |
dc.subject |
TOC-JUN-2024 |
en_US |
dc.title |
Bisindole-based small molecules as transmembrane anion transporters and potential anticancer agents |
en_US |
dc.type |
Article |
en_US |
dc.contributor.department |
Dept. of Chemistry |
en_US |
dc.identifier.sourcetitle |
Organic & Biomolecular Chemistry |
en_US |
dc.publication.originofpublisher |
Foreign |
en_US |