Molecular recognition and proteoglycan mimic arrangement: modulating cisplatin toxicity

dc.contributor.author	ANAND, SAURABH	en_US
dc.contributor.author	MARDHEKAR, SANDHYA	en_US
dc.contributor.author	BHOGE, PREETI RAVINDRA	en_US
dc.contributor.author	MISHRA, SANDEEP KUMAR	en_US
dc.contributor.author	KIKKERI, RAGHAVENDRA	en_US
dc.date.accessioned	2025-04-15T06:48:29Z
dc.date.available	2025-04-15T06:48:29Z
dc.date.issued	2024-04	en_US
dc.identifier.citation	Chemical Communications, 60(33), 4495-4498.	en_US
dc.identifier.issn	1359-7345	en_US
dc.identifier.issn	1364-548X	en_US
dc.identifier.uri	https://doi.org/10.1039/D4CC00464G	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/9472
dc.description.abstract	We have demonstrated that cisplatin (CP), an anticancer drug, showed a preference for binding the sulfated-L-iduronic acid (S-L-IdoA) unit over the sulfated-D-glucuronic acid unit of heparan sulfate. The multivalency of S-L-IdoA, such as in the proteoglycan mimic, resulted in distinct modes of cell-surface engineering in normal and cancer cells, with these disparities having a significant impact on CP-mediated toxicity.	en_US
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.subject	Chemistry	en_US
dc.subject	2024	en_US
dc.title	Molecular recognition and proteoglycan mimic arrangement: modulating cisplatin toxicity	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Chemical Communications	en_US
dc.publication.originofpublisher	Foreign	en_US