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Evaluating immune cells in physiological settings: Studying the neonatal immune landscapes and the effect of fever-range temperatures on T-cell differentiation

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dc.contributor.advisor BAL, VINEETA en_US
dc.contributor.author PHADKE, IRA en_US
dc.date.accessioned 2018-05-16T08:37:14Z
dc.date.available 2018-05-16T08:37:14Z
dc.date.issued 2018-05 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/995
dc.description.abstract The immune network is modulated by an n-dimensional matrix of genetic, epigenetic and environmental factors. In neonates, development occurs in an immunologically sterile environment. Their immune landscape is modelled predominantly by genetic and ethno-geographical factors. These inherent variations give rise to populations of immune subsets that are both tightly and loosely regulated. One such human population study, from 6 villages near Pune, showed interesting trends in frequencies of B, T, and innate cell subsets. Moreover, the data also presented correlations between frequencies of immune subsets that developmentally belong to distinct lineages, therefore raising questions about probable “common” interacting pathways. Conversely, post infection in vertebrates, a febrile response is generated on immunological challenge. Previous reports have demonstrated that hyperthermia augments immune responses of the innate and adaptive arms. However, the effect of temperature on T-cell fate determination is not known. The data presented here, suggests that the Th2 response is likely to be affected more significantly than the Th1 response at raised temperatures. Further quantitative studies need to be undertaken to decipher the molecular players that sense temperature fluctuations and activate downstream signaling in this pathway. en_US
dc.description.sponsorship DST INSPIRE en_US
dc.language.iso en en_US
dc.subject 2018
dc.subject Biology en_US
dc.subject Immunology en_US
dc.subject Neonatal immune system en_US
dc.subject Fever en_US
dc.subject T cell differentiation en_US
dc.title Evaluating immune cells in physiological settings: Studying the neonatal immune landscapes and the effect of fever-range temperatures on T-cell differentiation en_US
dc.type Thesis en_US
dc.type.degree BS-MS en_US
dc.contributor.department Dept. of Biology en_US
dc.contributor.registration 20131120 en_US


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  • MS THESES [1705]
    Thesis submitted to IISER Pune in partial fulfilment of the requirements for the BS-MS Dual Degree Programme/MSc. Programme/MS-Exit Programme

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