IISER Pune Digital Repository

A repository of scholarly research output from the Indian Institute of Science Education and Research (IISER) Pune.

Browse publications, theses, and other research output produced by the IISER Pune community.

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PUBLICATIONS & PATENTS 7245
THESES & PROJECT REPORTS 2999
Theses submitted to IISER Pune in partial fulfilment of the requirements of the BS-MS dual degree, MSc. and Ph.D programmes. Also, project reports submitted by the students.

Recent Submissions

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Sparse Identification of Nonlinear Dynamics for Digital Twin Applications in Solar Photovoltaic Systems
(IEEE, 2026-08) AbuBakr, Mir Muhammad Zaid; Rafiq, Fahid; APTE, AMIT; Sofi, Sahid Hameed; Shafi, Mohammad Sahil; Nahvi, Shahkar Ahmad; Dept. of Data Science
Digital Twin (DT) applications for solar photovoltaic (PV) systems require dynamic models that are compact, interpretable, and capable of adapting to changing environmental conditions. This paper investigates the use of Sparse Identification of Nonlinear Dynamics with control (SINDYc) as a data-driven modeling approach to support DT applications in solar PV systems. Considering a PV panel directly connected to a resistive load, the voltage and current are algebraically constrained, motivating a reduced-order formulation in which the output current is treated as the sole dynamic state, while solar irradiance and module temperature are modeled as exogenous inputs. Synthetic datasets with diverse excitation profiles are first employed to identify sparse nonlinear dynamic models. A key contribution of this work is the application and validation of the SINDYc framework using experimentally acquired real-time PV data, demonstrating its effectiveness beyond synthetic or simulated settings. Model performance is evaluated using error metrics to assess predictive accuracy and generalization across operating conditions. The results demonstrate that SINDYc can identify reduced-order dynamic models capable of capturing the effective behavior of the PV system, thereby supporting core DT applications such as real-time prediction, monitoring, and model updating. Limitations related to generalization under unseen real-world conditions are discussed, outlining directions for future improvement of DT fidelity.
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Evidence of 𝑍⁢𝑍⁢𝛾 Production and Observation of 4⁢ℓ⁢𝛾 in Proton-Proton Collisions at √𝑠=13 TeV
(American Physical Society, 2026-08) CMS Collaboration; Hayrapetyan, A.; DUBE, SOURABH; HAZARIKA, P.; KANSAL, B.; LAHA, A.; SHARMA, R.; SHARMA, SEEMA; VAISH, K.Y. et al.; Dept. of Physics
Evidence of the production of two 𝑍 bosons and a photon in proton-proton collisions is reported for the first time in CMS. The analysis uses data collected by the CMS experiment between 2016 and 2018 at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb−1. Evidence for the process 𝑝⁢𝑝→𝑍⁢𝑍⁢𝛾→4⁢ℓ⁢𝛾 (ℓ =𝑒, 𝜇), with an observed (expected) significance of 3.7 (3.1) standard deviations in a fiducial region defined by 𝑝𝛾T>20 GeV, |𝜂𝛾|<2.4, Δ⁢𝑅⁢(ℓ,𝛾)>0.5, 𝑚𝑍 between 60 and 120 GeV, and the invariant mass of either of the two 𝑍 bosons combined with the photon (𝑚𝑍𝛾) larger than 100 GeV, is reported. The measured (predicted) fiducial cross section is 60+27−22 ab (47.56±0.04 ab). Additionally, the inclusive production of 𝑝⁢𝑝→4⁢ℓ⁢𝛾 is studied by removing the 𝑚𝑍𝛾 requirement to include final state radiation where one 𝑍 boson decays to 2⁢ℓ⁢𝛾, yielding an observed (expected) significance of 5.0 (4.2) standard deviations and a measured (predicted) fiducial
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A multilevel formalism to model the hybrid E/M phenotypes in epithelial-mesenchymal plasticity
(Elsevier B.V., 2026-09) Hari, Kishore; Tripathi, Shubham; ANAND, VAIBHAV; Jolly, Mohit Kumar; Levine, Herbert; Dept. of Biology
Epithelial-mesenchymal plasticity is a cell-fate switching program that enables cells to adopt a spectrum of phenotypes ranging from epithelial (E) to mesenchymal (M), including intermediate hybrid E/M states. Hybrid E/M phenotypes are conducive to cancer metastasis, as they are associated with metastatic initiation, cancer stemness, drug resistance, and collective migration. Boolean models of the gene regulatory networks underlying epithelial-mesenchymal plasticity have yielded valuable insights into the dynamics of E and M phenotypes. However, these models are limited in their ability to capture hybrid phenotypes effectively, as they restrict gene expression to binary states. In contrast, hybrid E/M cells often exhibit partial expression of epithelial and mesenchymal markers. To overcome this limitation, we modified a threshold-based Boolean formalism to incorporate intermediate gene expression levels. The resulting multilevel model reveals novel hybrid steady states characterized by partial expression of both E and M genes, thereby expanding the phenotypic landscape beyond that represented by traditional Boolean approaches. Notably, these hybrid states exhibit lower frustration compared with their counterparts in classical Boolean models. By resolving dynamical degeneracy, we demonstrate that the hybrid states identified by the multilevel model are more stable. Furthermore, the multilevel hybrid states are found to be highly heterogeneous and more plastic than the Boolean hybrid states, with enhanced hybrid-to-hybrid plasticity that can better explain sustained collective migration during metastasis. These findings suggest that introducing minimal additional complexity into Boolean models can uncover previously hidden qualitative features of phenotypic landscapes governed by gene regulatory networks.
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Search for Associated Production of a Higgs Boson and Two Vector Bosons via Vector-Boson Scattering at √𝑠=13 TeV
(American Physical Society, 2026-09) CMS Collaboration; Hayrapetyan, A.; DUBE, SOURABH; HAZARIKA, P.; KANSAL, B.; LAHA, A.; SHARMA, R.; SHARMA, SEEMA; VAISH, K.Y. et al.; Dept. of Physics
A search for Higgs boson (𝐻) production in association with two vector bosons (𝑉 =𝑊, 𝑍) via vector-boson scattering (VBS) is presented using proton-proton collision data collected at √𝑠 =13 TeV by the CMS experiment, corresponding to an integrated luminosity of 138 fb−1. Events containing two forward jets consistent with VBS, a large-radius jet from the decay of a boosted 𝐻 to a pair of 𝑏 quarks, and zero, one, or two charged leptons coming from 𝑉 decays are selected. The process is excluded at 95% confidence level for observed (expected) values of the 𝑉⁢𝑉⁢𝐻⁡𝐻 coupling modifier 𝜅2⁢𝑉 outside the interval 0.40 <𝜅2⁢𝑉 <1.60 (0.34 <𝜅2⁢𝑉 <1.66), assuming standard model values for all other couplings, thus establishing a novel probe of the 𝑉⁢𝑉⁢𝐻⁡𝐻 interaction. Constraints are also set on the individual 𝜅2⁢𝑊 and 𝜅2⁢𝑍 coupling modifiers and on the allowed region in the 𝜅2⁢𝑊−𝜅2⁢𝑍 plane.
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Scaling of microtubule spirals driven by dyneins: collective effect of microtubule and motor mechanics
(The Royal Society, 2026-09) SONI, AMAN; YADAV, SHIVANI A.; ATHALE, CHAITANYA A.; Dept. of Biology
Molecular motor-driven spirals of actin filaments pinned at one end while driven along their length were seen to be scale-independent. The spiral radius and frequency dependence on force was predicted to follow a universal law, validated by actin–myosin experiments. However, the theory was primarily compared to acto-myosin spirals, assuming no effect of filament length and that motor velocity is additive with density. Here, we reconstitute microtubule spirals driven by dynein transport and end-pinning and find that spiral size scales with force with an exponent approximately ⁠, consistent with theoretical predictions. However, spiral radius scaling with length deviates from the theory and can be explained by a ‘variable persistence length’ model. The previously predicted exponent of frequency scaling with force approximately is not observed in experiments. A model that assumes constant collective transport velocity of motors regardless of density predicts the scaling exponent approximately ⁠, comparable to that observed experimentally. Our work demonstrates that microtubule motor systems deviate from the general scaling laws of cytoskeletal spirals predicted previously, based on both detailed mechanics of microtubules and collective force generation of motors.