IISER Pune Digital Repository

A repository of scholarly research output from the Indian Institute of Science Education and Research (IISER) Pune.

Browse publications, theses, and other research output produced by the IISER Pune community.

Email: libraryservices@iiserpune.ac.in

Communities in Digital Repository

Select a community to browse its collections.

Now showing 1 - 3 of 3

OTHER RESOURCES 612
PUBLICATIONS & PATENTS 7319
THESES & PROJECT REPORTS 3014
Theses submitted to IISER Pune in partial fulfilment of the requirements of the BS-MS dual degree, MSc. and Ph.D programmes. Also, project reports submitted by the students.

Recent Submissions

Access status: Metadata only ,
Particle transformers for identifying Lorentz-boosted Higgs bosons decaying to a pair of W bosons
(Springer Nature, 2026-10) CMS Collaboration; Hayrapetyan, A.; DUBE, SOURABH; HAZARIKA, P.; KANSAL, B.; LAHA, A.; SHARMA, R.; SHARMA, SEEMA; VAISH, K.Y. et al.; Dept. of Physics
A novel deep neural network classifier, a “particle transformer” (ParT), is introduced for the identification of highly Lorentz-boosted resonances reconstructed as single, multipronged jets in measurements and searches performed by the CMS Collaboration at the CERN LHC. Based on a self-attention mechanism that allows the model to weigh the importance of different particles, ParT is trained on a wide variety of topologies, notably demonstrating strong performance for the first time on jets originating from boosted Higgs boson decays to W bosons. The ParT algorithm achieves a tagging efficiency of more than 50% for such jets at a background efficiency of 1%, while maintaining decorrelation from the jet mass. A calibration is performed in proton-proton collision data collected by CMS at a center-of-mass energy of 13 TeV, with a data set corresponding to a total luminosity of 138 fb−1. Data-to-simulation selection efficiency scale factors are measured to be in the 0.9–1.0 range, with relative uncertainties between 7 and 23%. The tagging capability of ParT enhances the sensitivity of standard model measurements and searches for beyond-the-standard-model resonances decaying to hadronic diboson systems.
Access status: Metadata only ,
Combination of searches for nonresonant Higgs boson pair production in proton–proton collisions at
(IOP Publishing, 2026-09) CMS Collaboration; Hayrapetyan, A .; ALPANA, A.; DUBE, SOURABH; HAZARIKA, P.; KANSAL, B.; LAHA, A.; SHARMA, R.; SHARMA, SEEMA; VAISH, K.Y. et al.; Dept. of Physics
This paper presents a combination of searches for the nonresonant production of Higgs boson pairs (HH) in proton–proton collisions at a centre-of-mass energy of 13 TeV. The dataset was collected by the CMS experiment at the LHC from 2016 to 2018 and corresponds to a total integrated luminosity of 138 fb. The observed (expected) upper limit on the inclusive HH production cross-section relative to the standard model (SM) prediction is found to be 3.5 (2.5). Assuming all other Higgs boson couplings are equal to their SM values, the Higgs boson trilinear self-coupling modifier is constrained in the range at 95% confidence level (CL). Similarly, for the coupling modifier , which governs the interactions between two vector bosons and two Higgs bosons, we have excluded at more than five standard deviations for all values of . At 95% CL, assuming that the other couplings are equal to their SM values, is constrained in the range . This work also investigates HH production in several new physics scenarios, using the Higgs effective field theory (HEFT) framework. The HEFT framework is further exploited to study various ultraviolet complete models with an extended Higgs sector and set constraints on specific parameters. An extrapolation of the results in the expected integrated luminosity following the high-luminosity upgrade of the LHC is also reported.
Access status: Metadata only ,
Bioactive benzoxazinone-based hydrazone metal complexes: synthesis, characterization, DFT analysis, and molecular docking studies
(Springer Nature, 2026-10) Bhoomandla, Srinu; Bandi, Sirisha; Nagaveni, S.; Pandiri, Hanuman Prasad; Trivedi, Rashmi; Saha, Amrita; Konakanchi, Ramaiah; REDDY, MALLU CHENNA; Dept. of Chemistry
The strategic design of novel ligands is essential in the synthesis of innovative metal complexes, as it allows for precise metal coordination that imparts distinctive structural frameworks, tailored physicochemical characteristics, and enhanced biological functionalities, thereby unlocking new possibilities for advanced technological and therapeutic applications. This work introduces the design and exploration of a hydazide-hydrazone based ligand 2-aminonicotinaldehyde benzoxazinonyl acetic acid hydrazone (ABAH) and its novel Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Pd(II) complexes, which were comprehensively characterized using spectroscopic, physicochemical, and computational techniques. Spectral and DFT analyses support the coordination of ABAH acts as a neutral bidentate ligand through azomethine nitrogen and amide oxygen atoms. Based on the combined experimental and computational data, tentative octahedral geometries are proposed for the Co(II) and Ni(II) complexes, a distorted octahedral geometry is proposed for the Cu(II) complex, a tetrahedral geometries are proposed for the Zn(II) and Cd(II) complexes and a square-planar geometry for the Pd(II) complex. Molecular docking studies against HER2 and EGFR proteins revealed strong binding affinities, particularly for Ni(II) and Cu(II) complexes, corroborating their anticancer activities observed in vitro against multiple human cancer cell lines, with selective toxicity over normal HEK-293 cells. The Co(II) and Cd(II) complexes exhibited broad-spectrum antimicrobial efficacy surpassing standard drugs in some cases, while Ni(II) and Cu(II) complexes demonstrated strong antioxidant activity in the DPPH assay, although their activities were slightly lower than that of the reference standard ascorbic acid. Additionally, non-linear optical (NLO) properties derived from DFT calculations indicated enhanced hyperpolarizability in the metal complexes relative to the free ligand, suggesting potential applications in advanced optical materials. Overall, the results indicate that metal coordination substantially influences the structural, electronic, and biological properties of ABAH. The Ni(II) and Cu(II) complexes showed the most pronounced antioxidant and cytotoxic responses, while Co(II) complex exhibited notable antimicrobial activity. The combined experimental and computational findings provide a basis for further investigation of ABAH metal complexes as coordination-based bioactive systems, while additional structural, mechanistic, stability, and in vivo studies are required to establish their practical biomedical or materials applications.
Access status: Metadata only ,
Electrodeposited bismuth nanomaterials as binder free and scalable catalysts for highly selective CO2 to formate conversion
(Royal Society of Chemistry, 2026-10) Sihag, Anil Kumar; SINGH, YASHRAJ KUMAR; Kotob, Esraa; Khairunnisa, Sarah Zulfa; Ostermann, Markus; Guselnikova, Olga; Valtiner, Markus; Abdinejad, Maryam; Pichler, Christian M.; Dept. of Chemistry
Binder free and scalable Bi-based GDE catalysts were prepared for electrochemical CO2 reduction. Different deposition electrolytes result in variations in the initial structure, which converge to a similar nanoflower morphology in the active state.
Access status: Metadata only ,
Mitofusin-2 (MFN2) is a critical regulator of metabolic homeostasis in neuronal cells: A metabolomic and proteomic study
(Elsevier B.V., 2027-01) Kulkarni, Prakash G.; SAHOO, SOUMYA S.; Mohire, Vaibhavi M.; Sharma, Shilpy; CHUGH, JEETENDER; Banerjee, Tanushree; Sakharkar, Amul J.; Dept. of Chemistry
The role of mitofusin 2 (Mfn2) in mitochondrial metabolism and neurodegeneration is largely unknown. The current study probes the role of Mfn2 in mitochondrial biogenesis and metabolism in SH-SY5Y neuronal cells using multi-omics strategies. Mfn2 knockdown (KD) by siRNA treatment resulted into diverse proteomic and metabolomic changes. Furthermore, a battery of cellular and molecular analyses associated Mfn2-KD with increased oxidative stress, perturbed mitochondrial membrane potential and reduced mtDNA copy numbers in the neuronal cells. In addition, Mfn2-KD induced dramatic alterations in cell cycle profiles inclusive of proliferation and apoptosis. SWATH-MS-based analysis showed downregulation and upregulation of 11 and 22 differentially expressed proteins (DEPs), respectively, that serve in ribosomal biogenesis, translation, apoptosis, aging, TCA, and OXPHOS metabolic pathways. Among these proteins, TARBP emerged as a hub protein. 1H NMR-based metabolomic analysis showed alterations in 7 metabolites in the Mfn2-KD cells, which were associated with mitochondrial metabolism. Among these metabolites, taurine, a neuromodulator, was significantly downregulated after Mfn2-KD. Interestingly, supplementation of taurine restored the Mfn2-KD-induced deleterious alterations in mitochondrial physiology and cellular metabolomics in the neuronal cells. These results suggest the vital role of Mfn2 in mitochondrial functions in neuronal cells, and taurine emerges as a potential metabolite in Mfn2-linked mitochondrial dysfunction.